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Toxic and DNA-damaging activities of substances
Germany (bvmd) - Julius-Maximilians Universitaet, Wuerzburg
Department of Toxicology, Universitaet Wuerzburg, Versbacher Str. 9, 97078 Wuerzburg
Prof. Dr. Helga Stopper
Working Group Leaders of the Department (Depending on Choice of Substances)
Type of Research Project
- Basic science
What is the background of the project?
We work with cultured mammalian cells and investigate the toxic and/or genotoxic (DNA-damaging) properties and mechanisms of substances (environmental contaminants, possible pharmaceuticals, natural compounds). For example previous papers were published about the in vivo antigenotoxic effects of resveratol against genotoxins like diepoxybutane, mephedrone, methyl methanesulfonate and procarbazine or about the genotoxic activity of the new pharmaceutical FS1 in Salmonella/microsome test and mouse lymphoma (L5178Y) cells.
What is the aim of the project?
To gain knowledge about the mechanism of action in the toxicity of substances metabolism in different tissues
What techniques and methods are used?
Mammalian cell culture for cell proliferation analysis with different medias and various concentrations of test compounds; medium replacement, incubation, washing and centrifugation of test cells till fixation for fluorescence microscopy. Then we use fluorescence microscopy with numbers of nuclei and micronuclei in order to screen for potential genotoxic compounds. Possibly other performed techniques are mutation assays (monitoring of somatic mutations in vivo can be a biological marker useful in evaluating the cancer risk from exposure to environmental mutagens), immunfluorescence staining, etc.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Enthusiasm for lab work and science, intend to work carfullly, taking responsiblity for own work and material (including preparations and clean-up). Some prior lab experience would be helpful. There are no legal limitations. English must be at sufficient level (because of lab safety, ability for proper understanding and communication is mandatory
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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