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Updating invasive fungal infections in patients undergoing allogenic stem cell transplantation (alloSCT)
Universita degli Studi di Brescia
Chair of Haemathology; unit of bone marrow transplantation; Padiglione Malattie Infettive, II piano, Spedali Civili, Brescia (BS)
Prof. Dr. Domenico Russo
Dr Michele Malagola
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Invasive fungal infections represent a key point in the management of patients undergoing allo-SCT. They represent a major issue in the treatment of patients undergoing allo-SCT as they may significantly increase the morbidity and the mortality of the procedure. Traditionally, fungal infections sustained by Candida species represented the major problem. Since the introduction of chronic prophylaxis with fluconazole the incidence of Candida infections dropped below th 5% of all the cases of invasive fungal infections during the first 100 days from the allo-SCT. In the meantime, infections sustained by Aspergillus species significantly increased and they represent nowadays the major problem both during the aplasia phase and during the first year after transplant during immune reconstitution. Thus, a careful monitoring and an effective prophylaxis of these infections as well as a prompt anti-fungal therapy are necessary for the clinical management of these patients.
What is the aim of the project?
To monitor the incidence and the treatment outcome of invasive fungal infections in allotransplanted patients.
What techniques and methods are used?
Clinical, laboratory and radiological data colletions statistical analysis with specific software (e.g. NCSS)
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will not perform diagnostic procedures (such as biopsies), but will visit the patient, collect clinical and laboratory data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
For the use of students considering participating in the project, further information can be found from the following articles (please add specific articles): Haematologica. 2015 Feb;100(2):284-92. doi: 10.3324/haematol.2014.113399. Pre-chemotherapy risk factors for invasive fungal diseases: prospective analysis of 1,192patients with newly diagnosed acute myeloid leukemia (SEIFEM 2010-a multicenter study). SEIFEM Group (Sorveglianza Epidemiologica Infezioni Fungine in Emopatie Maligne). Biol Blood Marrow Transplant. 2014 Aug;20(8):1080-8. doi: 10.1016/j.bbmt.2014.02.018. Epub 2014 Feb 26. Primary prophylaxis of invasive fungal diseases in allogeneic stem cell transplantation: revised recommendations from a consensus process by Gruppo Italiano Trapianto Midollo Osseo (GITMO).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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