Projects
Name
Homeostatic model assessment of insulin resistance as a predictor of metabolic syndrome
University
Universidad Nacional Federico Villareal
Domain
Endocrinology
Departement
Servicio de Endocrinolog
Head
Dr. Carlos Del Aguila
Tutor
Dr. Carlos Del Aguila
Languages
English, Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes Yes Yes Yes Yes No No No No No Yes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The prevalence of obesity among children and adolescents is progressively increasing around the world. One of the important consequences of obesity is the development of insulin resistance (IR). This condition has a multifactorial pathogenesis and is associated with cardiovascular risk, diabetes, hypertension, polycystic-ovary syndrome and a shorter lifespan. Aim: To evaluate insulin resistance according to homeostasis model assessment of insulin resistance index HOMA-IR in obese children and adolescents with or without metabolic syndrome. Techniques: A group of obese children and adolescents will be recruited and metabolic syndrome will be diagnosed according to the modified WHO criteria adapted for children and adolescents. Insulin resistance will be calculated using the HOMA-IR (homeostasis model assessment of insulin resistance).
What is the aim of the project?
To evaluate insulin resistance according to homeostasis model assessment of insulin resistance index HOMA-IR in obese children and adolescents with or without metabolic syndrome.
What techniques and methods are used?
A group of obese children and adolescents will be recruited and metabolic syndrome will be diagnosed according to the modified WHO criteria adapted for children and adolescents. Insulin resistance will be calculated using the HOMA-IR (homeostasis model assessment of insulin resistance).
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Student will analyze and discuss insulin resistance according to homeostasis model assessment of insulin resistance index HOMA-IR in obese children and adolescents with or without metabolic syndrome.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings on the topics of Pediatrics, Endocrinology and metabolism.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
We accept students with clinical experience. No legal limitations.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- Gao M; Zhao Z; Lv P; Li Y; Gao J; Zhang M; et al. Quantitative combination of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress. Redox Biol 2015;6:206-217.
- Rosen JB; Ballantyne CM; Hsueh WA; Lin J; Shah AK; Lowe RS; et al. Influence of metabolic syndrome factors and insulin resistance on the efficacy of ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome and atherosclerotic coronary heart disease risk. Lipids Health Dis 2015;14(1).
- Goel P. Insulin resistance or hypersecretion? The βIG picture revisited. J Theor Biol 2015;384:131-139.