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The role of Wnt signaling pathway in epithelial to mesenchymal transition (WNT4EMT)
Croatia (CroMSIC) - University of Zagreb, Zagreb
Department of Biology / Laboratory of Neurooncology, School of Medicine Zagreb
Prof.dr.sc. Mario Vuksic, Prof.dr.sc. Floriana Bulic - Jakus
Prof.dr.sc. Nives Pecina - Slaus
English (Croatian, German, French also accepted)
Type of Research Project
- Basic science
What is the background of the project?
What is the aim of the project?
In the proposed research we aim to determine the involvement of Wnt signaling in the process of epithelial-to-mesenchymal transition (EMT) which is responsible for the invasion and progression of brain tumors. The classical Wnt pathway has a particularly tight link with EMT. Wnt pathway is one of the basic cellular pathways whose misregulation plays important roles in tumorigenesis.
What techniques and methods are used?
DNA isolation from tumor tissue and blood, spectrophotometry, polymerase chain reaction (PCR)/ loss of heterozygosity (LOH), gel electrophoresis, immunohistochemistry, High resolution melting (HRM).
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Program provides students the insight into scientific research, understanding of laboratory techniques, analysis and practical application of acquired knowledge, which serves the purpose of training young scientist in the field. The student will acquire competency equipped with theoretical knowledge and practical skills. In order to achieve above mentioned objectives, prior to the start of the experiment in the laboratory student will be provided with a distinctive theoretical knowledge of the wnt signaling and cancer genetics, and about methodology and techniques used. Student should be prepared to work in the laboratory by reading recommended literature.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in biochemistry and molecular biology techniques is required. Scientific report is demanded after the exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Vogelstein B
- Papadopoulos N
- Velculescu VE
- Zhou S
- Diaz LA Jr
- Kinzler KW. Cancer genome landscapes. Science. 201;339(6127):1546-58. doi: 10.1126/science. 1235122
- Pecina-Slaus N
- Kafka A
- Tomas D
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