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Autophagy in endometriosis
Thailand (IFMSA-Thailand) - Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok
Basic Medical Science, Vajira Hospital, Navamindradhiraj U.,Anatomy, Mahidol U.
Assist. Prof. Sumet Vajanarodjana, PhD
Bongkoch Turathum, M.Sc (Anatomy and Structural Biology) Benjamart Pratoomthai, Ph.D (Anatomy and Structural Biology)
Type of Research Project
- Basic science
What is the background of the project?
Endometriosis (EM) is an abnormal growth of endometrial tissue at ectopic sites in the peritoneal cavity that causes severe pain and sometimes obstruction of the bowel, uterus, and ovary. This disease is a major health problem which causes pain and infertility in women. Although, the exact mechanisms for the development of endometriosis are still unclear. It is known that estrogen stimulates the growth of endometriotic tissue. In contrast, progesterone induces the differentiation of both endometrial stromal and epithelial cells and reduces cell proliferation. Drug treatments of endometriosis include contraceptive steroids, agonists of gonadotropin-releasing hormone (GnRH-a), Danazol, and Progestin. Depo- medroxyprogesterone acetate (DMPA) is a progestin-only contraceptive that provides high reduction of pelvic pain in endometriotic patients. Despite the use and effectiveness of DMPA, its precise pharmacological action is not fully understood. Autophagy is a physiological process that causes degradation and recycling of cellular components. Several studies found that autophagy plays a role in many cancers. In this study, we aim to investigate the expression of autophagic markers in the endometrium of women with and without endometriosis as well as study the effects of DMPA on autophagic markers in eutopic and ectopic endometrium of endometriotic women. Immunohistochemistry and western blot will be used in this research.
What is the aim of the project?
To study the pathogenesis of endometriosis in order to develop the new treatment option.
What techniques and methods are used?
- Immunohistochemistry - Western Blot
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participate and work as a team in a lab.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Students must have pipetting skills and attend at least 80% of laboratory sessions.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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