Projects
Name
Identification of autoantibodies in neurological diseases
University
Germany (bvmd) - Ruhr-Universitaet, Bochum
Domain
Biochemistry
Departement
Medical Proteom-Center
Head
Prof. Dr. Katrin Marcus, katrin.marcus@rub.de
Tutor
Dr. Caroline May, Caroline.May@rub.de
Languages
English
Duration
8 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes No Yes Yes Yes Yes No Yes Yes Yes No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The research project focuses on a stable memory function of the body, the determination of autoantibodies in the blood of patients, which are easily accessible and can be easily measured with protein microarrays, ELISA, or other methods with as little as 100 ?l blood.
The identification of disease related antibodies regarding brain diseases has just started, e.g. with the introduction of antibodies against aquaporin-4 it is possible to identify an entity of multiple sclerosis with a clear implication for therapy and prognosis. The importance of antibodies for neurological diseases was further underlined by the identification of antibody inducing different forms of dementia (e.g. NMDA-related dementia). We set out to utilize protein microarrays in a case-control study for Amyotrophic lateral sclerosis. We identified 20 candidate proteins that differentiate between the study groups with 100% specificity and 99.9% sensitivity (May, et al., 2014).
What is the aim of the project?
-
What techniques and methods are used?
-
What is the role of the student?
What are the tasks expected to be accomplished by the student?
-
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic computer skills are required. Basic laboratory experience would be a plus. Fluent spoken and written English.
Please read the stated scientific reports:

Abel, L., S. Kutschki, M. Turewicz, M. Eisenacher, J. Stoutjesdijk, H. E. Meyer, D. Woitalla, and C. May. 'Autoimmune Profiling with Protein Microarrays in Clinical Applications', Biochim Biophys Acta, 2014.

May, C., E. Nordhoff, S. Casjens, M. Turewicz, M. Eisenacher, R. Gold, T. Brüning, B. Pesch, C. Stephan, D. Woitalla, B. Penke, T. Janáky, D. Virók, L. Siklós, J. I. Engelhardt, and H. E. Meyer. 'Highly Immunoreactive Igg Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array', PLoS One Vol. 9, No. 2, e89596, 2014. The tutor would like to have students who stay longer than four weeks. She will accept students up to 12 weeks. The research exchange has to be a mandatory integral part of your studies in order to be accepted!!!
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
Articles
- May; C.; E. Nordhoff; S. Casjens; M. Turewicz; M. Eisenacher; R. Gold; T. Brüning; B. Pesch; C. Stephan; D. Woitalla; B. Penke; T. Janáky; D. Virók; L. Siklós; J. I. Engelhardt; and H. E. Meyer. 'Highly Immunoreactive Igg Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array'; PLoS One Vol. 9; No. 2; e89596; 2014
- Abel; L.; S. Kutschki; M. Turewicz; M. Eisenacher; J. Stoutjesdijk; H. E. Meyer; D. Woitalla; and C. May. 'Autoimmune Profiling with Protein Microarrays in Clinical Applications'; Biochim Biophys Acta; 2014