Study of molecular genetic markers of chronic myeloid leukemia: gene toxicity identification by DNA-assay
Russian Federation (HCCM Russia) - Bashkir State Medical Academy, Ufa
Department of Oncohaematology, Research Institute of Occupational Health and Human Ecology
Ph. D. Prof. Ahat B.Bakirov
Dr. Denis O.Karimov
4 weeks
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Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Chronic myeloid leukemia, also known as chronic myelogenous leukemia, is a type of cancer that starts in certain blood-forming cells of the bone marrow. In Chronic myeloid leukemia, a genetic change takes place in an early (immature) version of myeloid cells - the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes). This change forms an abnormal gene called BCR-ABL, which turns the cell into a Chronic myeloid leukemia cell. The leukemia cells grow and divide, building up in the bone marrow and spilling over into the blood. In time, the cells can also settle in other parts of the body, including the spleen. Chronic myeloid leukemia is a fairly slow growing leukemia, but it can also change into a fast-growing acute leukemia that is hard to treat. Most cases of CML occur in adults, but very rarely it occurs in children, too. In general, their treatment is the same as for adults and nowadays there are still no methods for early diagnosis of the disease. So this project was designed to research this problem more deeply.
What is the aim of the project?
The aim of the project is to study molecular genetic markers to identify the risk of chronic myeloid leukemia and apply the results of the investigation to the practical medicine for early diagnostics of chronic myeloid leukemia.
What techniques and methods are used?
- Isolation of deoxyribonucleic acid (DNA) - Amplification of nucleic acids - Real-time polymerase chain reaction (PCR)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Taking biomaterials from the patient and working in the laboratory: improving such skills like Isolation of deoxyribonucleic acid (DNA), amplification of nucleic acids, real-time polymerase chain reaction (PCR).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Examination in Human Genetics , Hematology and Oncology ( or final tests) passed
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
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