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Study of role of cytokine genes in the formation of arthritis in adults and children
Russian Federation (HCCM Russia) - Bashkir State Medical Academy, Ufa
Bashkir State Medical University, Central Scientific Research Laboratory, Ufa, Lenina St,3
P.h.D. Valentin N. Pavlov
P.h.D. Ksenia V. Danilko
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Rheumatoid arthritis is a chronic systemic disorder of unknown etiology. This disease affects about 1% of the population worldwide, most commonly middle-aged women. It is characterized by chronic inflammation of the synovium, particularly of small joints, which often leads to destruction of articular cartilage and juxtaarticular bone.1The clinical and laboratory features are suggestive of an autoimmune disease. However, the autoantigen is still unknown, hampering specific immunomodulation as a straightforward therapeutic approach. The cytokine network in rheumatoid arthritis is a complex field, with a lot of cytokines showing pleiotropic actions and many different targets that caused by the genetic predesposition which is one of the factors thaw we are study so deeply, cuase targeting the cytokine disbalance might represent a solid way to control this disease
What is the aim of the project?
The aim of the project is to identify molecular genetic factors predisposed to the development of rheumatoid arthritis
What techniques and methods are used?
- Isolation of deoxyribonucleic acid (DNA) - amplification of nucleic acids - real-time polymerase chain reaction (PCR).
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Taking biomaterials from the patient and working in the laboratory. improving such skills like Isolation of deoxyribonucleic acid (DNA), amplification of nucleic acids, real-time polymerase chain reaction (PCR).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Exam in Human Genetics (or final test) passed
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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