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An assessment of immune response to nonconjugate and conjugate vaccine in patients with immunodeficiency disorders.
Poland (IFMSA-Poland) - Medical University of Lublin, Lublin
Department of Clinical Immunology and Immunotherapy
Professor Jacek Rolinski
Professor Piotr Pozarowski and Ewelina Grywalska
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Vaccinations are recommended in immunocompromised patients however, the result of immune response is poor . Since 2012, both the 13-valent pneumococcal conjugate vaccine (PCV13) and PPV23 have been recommended for pneumococcal infection prevention in adult patients with immunodeficiency disorders. The effectiveness of PCV13 in immunocompromised adult patients has not been assessed. Students will assess efficiency of the immune response to PCV13 in untreated CLL patients versus healthy subjects. Both groups will be evaluated for: the levels of specific pneumococcal antibodies, the levels of IgG and IgG subclasses, selected peripheral blood lymphocyte subpopulations including the proportion of plasmablasts before and after immunization. The peripheral blood samples will be use for the following tests: 1) serum specific pneumococcal antibody titres before vaccination and 30 days after vaccination, 2) proportion of plasmablasts, defined as CD19+/IgD-/CD27++ before vaccination and 7 days after vaccination, 3) serum total IgG as well as IgG1, IgG2, IgG3, IgG4 levels before vaccination and 30 days after vaccination.
What is the aim of the project?
The aim of the study is to compare the immune response vaccines in adult patients with immunodeficiency disorders and healthy subjects.
What techniques and methods are used?
Routine immunophenotyping of peripheral blood lymphocytes Complete blood count tests and measurements of serum IgA, IgM, IgG, IgG1, IgG2, IgG3, IgG4 levels, will be conducted before, and 1 month after vaccination.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-involvement.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge of the basics of immunology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Antibody and Plasmablast Response to 13-Valent Pneumococcal Conjugate Vaccine in Chronic Lymphocytic Leukemia Patients ? Preliminary Report - PLOS ONE | DOI:10.1371/journal.pone.0114966 December 15 2014
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