Projects
Name
Clinical determinants of neointima thickness after stent implantation evaluated by optical coherence tomography
University
Catalonia (AECS) - University of Barcelona (UB) - Hospital Clinic, Barcelona
Domain
Cardiology
Departement
Cardiology department
Head
Manel Sabate
Tutor
Salvatore Brugaletta
Languages
English accepted (Spanish not mandatory)
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Optical coherence tomography (OCT) is a light-based imaging modality that can provide in vivo high-resolution images of coronary stents, with detailed information about struts apposition and tissue coverage. Pathological studies have suggested that the absence of stent strut coverage due to delayed vascular healing and the persistence of fibrin may be the most important determinants of late stent thrombosis, together with lesion and procedure-related settings. For this reason, coverage at strut-level analysis by OCT is the most common surrogate endpoint in OCT studies, providing a measurable variable for the comparison between different stents and being also an important parameter for the approval of new drug eluting stents by regulatory agencies. Little is known about those clinical determinants of such neointima thickness, so in this project we try to study the factors that affect the progression of the thickness and how optical coherence tomography can help to identify those alterations. What is the aim of the project? To identify clinical predictors of stent neointima thickness and to study the results obtained. What techniques and methods will be used? It is a retrospective study, which will use statistical analysis to identify clinical predictors of neointima thickness. Optical coherence tomography will also be used.
What is the aim of the project?
To identify clinical predictors of stent neointima thickness and to study the results obtained.
What techniques and methods are used?
It is a retrospective study, which will use statistical analysis to identify clinical predictors of neointima thickness. Optical coherence tomography will also be used.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The role of the student will be to fulfill a database with all the clinical, procedural and optical coherence tomography data collected in our Institution during the last 3 years. He will perform statistical analysis in order to identify predictors of stent neointima thickness.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures on optical coherence tomography analysis and evaluation will be given to the student.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The role of the student will be to fulfill a database with all the clinical, procedural and optical coherence tomography data collected in our Institution during the last 3 years. He will perform statistical analysis in order to identify predictors of stent neointima thickness.
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/25634905
- http://www.ncbi.nlm.nih.gov/pubmed/25686520
- http://www.ncbi.nlm.nih.gov/pubmed/25616924