Screening of chemical compounds with potential anticancer or antibacterial activities
Czech Republic (IFMSA CZ) - Palacky University, Olomouc
Institute of molecular and translational medicine, Faculty of Medicine Olomouc
Hajduch Marian M.D., Ph.D.
Petr Konecny, M.Sc.
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
Screening of different chemical agents for their interesting properties, especially those with anticancer and antibacterial activity. Studying of specific mechanism of activity, regarding cell cycle analysis and other methods.
What is the aim of the project?
Development of new anticancer drugs.
What techniques and methods will be used?
Flow cytometry, tissue cultures. For the use of students considering participating in the project, further information can be found from the following articles:

-SPENEROVA, M., P. DZUBAK, J. SROVNAL, L. RADOVA, R. BURIANOVA, P. KONECNY, S. SALKOVA, Z. NOVY, D. POSPISILOVA, J. STARY, B. BLAZEK, J. HAK, T. VOTAVA, P. TIMR, E. KAISEROVA, E. BUBANSKA, V. MIHAL a M. HAJDUCH. Combination of prednisolone and low dosed dexamethasone exhibits greater in vitro antileukemic activity than equiactive dose of prednisolone and overcomes prednisolone drug resistence in acute childhood lymphoblastic leukemia. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2012, 156, (DOI: 10.5507/bp.2012.059). ISSN 1213-8118. IF (2011): 0.702. DEDIKACE: IGA NS 9939, IGA UP_LF_2012_018, BIOMEDREG CZ.1.05/2.1.00/01.0030.

-NAUŠ, P., O. CALETKOVÁ, P. KONEČNÝ, P. DŽUBÁK, K. BOGDANOVÁ, M. KOLÁŘ, J. VRBKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, P. PERLÍKOVÁ, M. HAJDÚCH a M. HOCEK. Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. Journal of Medicinal Chemistry. 2014, 57(3), 1097-1110. ISSN 0022-2623. IF (2012): 5.614. DEDIKACE: P207/11/0344, TE01020028, CZ.1.05/2.1.00/01.0030, RVO: 61388963.

-PERLÍKOVÁ, P., P. KONEČNÝ, P. NAUŠ, J. SNÁŠEL, I. VOTRUBA, P. DŽUBÁK, I. PICHOVÁ, M. HAJDÚCH a M. HOCEK. 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm. 2013, 4(11), 1497-1500. ISSN 2040-2503. IF (2012): 2.722. DEDIKACE: RVO:61388963, GAČR P207/11/0344,EU-PF7 no. 241587, BIOMEDREG CZ.1.05/2.1.00/01.0030.

-TOMÁNKOVÁ K, KOLÁŘOVÁ H, PIŽOVA K, BINDER S, KONEČNY P, KRIEGOVA E, MALINA L, HORAKOVA J, MALOHLAVA J, KEJLOVA K, JIROVA D. Cytotoxicity and Antioxidative Effects of Herbal and Fruit Extracts In Vitro, Food Biophysics (2014) 9:267?276, DOI 10.1007/s11483-014-9349-0 IF (2013): 1.551
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement

Type of students accepted
This project accepts:
- Medical students
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