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Role of Long Non-coding RNA in Heart Failure and Cardiac Fibrosis
Taiwan (FMS-Taiwan) - National Taiwan University, Taipei
Graduate Institute of Pharmacology
Type of Research Project
- Basic science
What is the background of the project?
Cardiac fibrosis plays a critical role in the pathogenesis of heart failure (HF). Current diagnostic and treatment options for cardiac fibrosis, however, are very limited. Long non-coding RNAs (lncRNA) are a heterogeneous group of non-coding transcripts longer than 200 nucleotides, which have been shown to be functional and involved in specific physiological and pathological processes through epigenetic, transcriptional and post-transcriptional mechanisms. While the roles of lncRNAs in human diseases including cancer and neurodegenerative disorders are 1 c/o WMA B.P, 63,01212 Ferney-Voltaire CDEX –FRANCE Tel. +33 (450) 04 47 59 Fax. +33 (450) 40 59 37 www.ifmsa.org beginning to emerge, it remains unclear how lncRNA regulation contributes to cardiovascular pathology such as cardiac fibrosis and heart failure.
What is the aim of the project?
To investigate the functional roles of lncRNAs in the pathogenesis of cardiac fibrosis and heart failure.
What techniques and methods are used?
Next-generation sequencing, cell culture, transfection, animal surgery, genome editing (CRISPR/Cas9), qPCR, Western blot, immunohistochemistry.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The students are expected to learn the background knowledge about non-coding RNA biology and the pathophysiology of heart failure. They will be conducting experiments independently under the supervision of the senior lab members and the PI. They will be presenting their project at the lab meeting at the end of the research exchange.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Journal readings, lab meetings, group discussions.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Biology and basic molecular biology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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