Projects
Name
Immunomodulation of cardiometabolic disorders
University
Spain (IFMSA-SPAIN)-University of Valencia, Valencia
Domain
Pharmacology
Departement
Pharmacology, University of Valencia,
Head
Pilar D Ocon
Tutor
Maria Jesus Sanz
Languages
English and/or Spanish.
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No Yes Yes No No Yes No No No No No
Type of Research Project
- Basic science
What is the background of the project?
According to the World Health Organization, by 2030 nearly 23.6 million people will die from cardiovascular disorders. Furthermore, about a fifth of the world’s adult population are thought to have metabolic syndrome, a cluster of factors associated with an increased risk of type 2 diabetes and cardiovascular disease.This increase in cardiometabolic disorders exerts a great burden on people, healthcare organisations, and society in general. However, cardiometabolic disorders are largely preventable, and a better understanding of the factors associated in their physiopathogenesis and implementation of interventions to modify these factors will be critical in tackling the current epidemic.
What is the aim of the project?
The main techniques and methods that will be used in this project will include flow cytometry as well as immunostaining techniques.
What techniques and methods are used?
The main techniques and methods that will be used in this project will include flow cytometry as well as immunostaining techniques.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will know how to perform different staining techniques and to learn how to interpret the results obtained from them and other studies such as cytometry flow technique. The techniques that will be expected to achieve by the end of the exchange program will be the basic management for the flow cytometry applied in the immunophenotyping field.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge about immunology
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- Escudero P; Martinez de Marañón A; Collado A; Gonzalez-Navarro H; Hermenegildo C; Sanz MJ et all. Combined Sub-Optimal Doses of Rosuvastatin and Bexarotene Impair Angiotensin II-Induced Arterial Mononuclear Cell Adhesion Through Inhibition of Nox5 Signaling Pathways and Increased RXR/PPARα and RXR/PPARγ Interactions. Antioxidants & Redox Signaling 2015.
- Rius C; Company C; Piqueras L; Cerdá-Nicolás JM; González C; Sanz MJ et all. Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium. Thorax 2013; 68(2): 177-86
- Martínez-Hervás S; Núñez L; Andrés-Blasco I; Piqueras L; Sanz MJ; González- Navarro H et all. Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis.. Cardiovasc Res 2014; 103(2):Cardiovasc Res 2014; 103(2): 324-36