Projects
Name
Study of alterations in intracellular signaling in Huntington
University
Catalonia (AECS) - University of Barcelona (UB) - Hospital Clinic, Barcelona
Domain
Neurology
Departement
Cell Biology, Immunology and Neurosciences
Head
Gustavo Egea
Tutor
Esther Perez Navarro
Languages
English, (Spanish and Catalan accepted but not mandatory)
Duration
12 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes
Type of Research Project
- Basic science
What is the background of the project?
Huntington s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the exon-1 of the huntingtin gene. Striatal projection neurons are the main affected population, but the molecular mechanisms that account for this specific vulnerability are not fully caracterized. In the last years we have characterized several kinases and phosphatses who s function is altered in the brain of mouse models and HD patients. Nowadays, we are interested in analyzing whether functions regulated by these kinases and phosphatases are altered in HD such as: 1) Protein translation; 2) nuclear morphology and transcription. and 3) regulation of motor and cognitive functions. We try to modulate these proteins in order to improve these functions in HD mouse models.
The aim of the project is to identify new therapeutic targets for the treatment of Huntington s disease based on intracellular signaling alterations.
Used Techniques are cell culture, transfection, mouse models, Western blot, immunocytochemistry, immunohistochemistry, PCR, protein extraction
What is the aim of the project?
The aim of the project is to identify new therapeutic targets for the treatment of Huntington’s disease based on intracellular signaling alterations.
What techniques and methods are used?
Cell culture, transfection, mouse models, Western blot, immunocytochemistry, immunohistochemistry, PCR, protein extraction
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student is to help PhD students and/or Post-doctoral researcher in several techniques in the laboratory and to understand what the aim of the project is. He/she is expected to learn the techniques and to have the capacity of interpret and discuss the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge in cell biology, neuronal function in the role of kinases and phosphatases.
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/21632937
- http://www.ncbi.nlm.nih.gov/pubmed/21835884
- http://www.ncbi.nlm.nih.gov/pubmed/23896721
- http://www.ncbi.nlm.nih.gov/pubmed/26223799
- http://www.ncbi.nlm.nih.gov/pubmed/25449908