Projects
Name
Synergistic effect of cold and hypoxia on tissue repair
University
Catalonia (AECS) - University of Barcelona (UB) - Sciences Faculty, Barcelona
Domain
Physiology
Departement
Department of Physiology and immunology,
Head
Prof. Gines Viscor
Tutor
Prof. Gines Viscor and Dr. Joan Ramon Torrella
Languages
English (required), Spanish, Catalan, Portuguese, French and Italian
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Previously we studied the role of intermittent hypobaric hypoxia on the recovery from induced muscle damage in rats. We intend now to focus on the muscle and tendon injuries to deepen where our findings have provided more positive results, since studies in rats suggest that the regenerative process largely depends on the activation of local
progenitors (satellite cells). This project integrates two intervention studies, one with a more basic approach and the second as a direct clinical application.
Thus, in one of the subprojects we will study the recovery of Achilles tendon injuries in humans whereas in the
other subproject it is proposed to study the evolution of muscle damage induced in male and female rats according to the protocol established in the previous funded project. In
both cases we will monitor the possible changes triggered by a combined treatment with cold and intermittent hypobaric hypoxia.

We will check out the effectiveness of the synchronous application of two external stimuli cold and hypobaric hypoxia. Since both environmental factors (geographical altitude and low temperature) always acted together throughout the evolution of life in our planet, it is possible to speculate about a great capacity for stimulation of sensory pathways and the consequent activation of homeostatic responses when both environmental factors act simultaneously.
Techniques: exposure to hypoxia (hypobaric chamber) and cold (temperature regulated room). Blood and muscle sampling, histochemical and biochemical analysis of plasma and skeletal muscle samples.
What is the aim of the project?
We will check out the effectiveness of the synchronous application of two external stimuli cold and hypobaric hypoxia. Since both environmental factors (geographical altitude and low temperature) always acted together throughout the evolution of life in our planet, it is possible to speculate about a great capacity for stimulation of sensory pathways and the consequent activation of homeostatic responses when both environmental factors act simultaneously.
What techniques and methods are used?
Exposure to hypoxia (hypobaric chamber) and cold (temperature regulated room). Blood and muscle sampling, histochemical and biochemical analysis of plasma and skeletal muscle samples.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
To participate in the experimental set-up. Contribute to day to day procedures and sampling protocols and help to the research team by supporting them in the different analytical procedures.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Specific laboratory tasks will be assigned and programmed according to the previous knowledge and experience of each admitted student
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/25318779
- http://www.ncbi.nlm.nih.gov/pubmed/25266982
- http://www.ncbi.nlm.nih.gov/pubmed/24947505
- http://www.ncbi.nlm.nih.gov/pubmed/24373840