[Veracruz] Effect of Telmisartan in anal sphincter. Study of gastro-neuro motility
Universidad Veracruzana Campus Veracruz
GI motility and digestive Physiology Lab, Bioresearch Institute Universidad Veracruzana
Dr. Jose Maria Remes Troche
Dr. Jose Maria Remes Troche
English, Spanish
4 weeks
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Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Studies in rats have shown that angiotensin II may be an important neuro-humoral regulator on the base IAS tone and angiotensin II ATI-R antagonist such as losartan decreased IAS pressure. However the role of ATI-R antagonizing in the human sphincter is not known.
What is the aim of the project?
The aim of the project is to evaluate the effects of Telmisartan an ATI-R antagonist which has a half-life of 24 hours in anorectal physiology in patients with anal sphincter hypertension as well in a group of asymptomatic volunteers.
What techniques and methods are used?
A pilot study is performed in patients with ano sphincter hypertension and chronic proctalgia (according to Rome III ontena) and healthy subjects. All subjects undergoes a basal 3D resolution manometry, then they receive the drug and 2nd manometry is perfomed.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Requirements will be only the interest of the student,attendance and punctuality.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
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