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Immunohistochemical analysis of myocardial infarction on a model of moderate alcohol consumption in rats
Croatia (CroMSIC) - University of Split, Split
Department of anatomy, histology and embryology, University of Split School of Medicine
Professor Ivica Grkovic, MD, PhD
Dr. Natalija Filipovic, Dr. Katarina Vukojevic, Dr. Nikola Kljucevic
Type of Research Project
- Basic science
What is the background of the project?
In vivo, effects of 'pretreatment' with various wines on proliferative phase of myocardial recovery in chronic models of myocardial damage will be examined. Three weeks before infliction of the myocardial damage, the animals will be consuming ad libitum standard diet and different test beverages (macerated and non-macerated white wines). Besides the groups of animals receiving selected test wine, there will be a control groups receiving water. Trans-abdominal diaphragmatic microsurgical approach will be employed in order to cause chronic injury of the rat myocardium. Histological characteristics of the myocardial post-damage healing process will be assessed employing multiple immunohistochemistry methods at fluorescent microscopy levels.
What is the aim of the project?
The aim of the project is to assess the effect of moderate wine consumption on the quality of healing following the ischemic damage of the myocardium. Particular attention will be focused to the acute inflammatory reaction of the infracted area. A battery of immunohistochemical markers will be used to compare infarcts of animals that consumed wines with control animals.
What techniques and methods are used?
Students will participate in performing basic histology and multiple immunohistochemistry methods in addition to microscopy and image capturing/analysis techniques. Classical histological and immunohistochemical techniques will be used.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
At least a second year medical student with passed anatomy, histology and neuroscience.
We accept one student per exchange period.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Aljinovic J
- Vukojevic K
- Kosta V
- Guic MM
- Saraga-Babic M
- Grkovic I. (2010) Histological differences in healing following experimental transmural infarction in rats. Histol Histopathol. 25(12):1507-17
- Grkovic I. (2014) Isoflurane post-conditioning stimulates the proliferative phase of myocardial recovery in an ischemia-reperfusion model of heart injury in rats. Histol Histopathol. 29(1):89-99
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