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Evaluation of the effects of pharmacologically active agents in the ageing process of eukaryotic cells
Greece (HelMSIC) - National and Kapodistrian University of Athens, Athens
Department of Pharmacology, Medical School University of Athens,
Professor Nikolaos Sitaras
Associate Professor Ekaterini Tiligada
Type of Research Project
- Basic science
What is the background of the project?
Ageing involves cellular and molecular mechanisms that are conserved among species and have been extensively studied during the past decades (Wasko BM, Kaeberlein M. FEMS Yeast Res 2014; 14:148-59); yet the effects of pharmacologically active agents remain elusive.
As such, the purpose of the project is to check individually various parameters and molecular pathways involved in ageing using different drugs and evaluate the results.
To evaluate the effects of pharmacologically active agents on various parameters that characterize ageing in eukaryotic cells using yeast as an experimental model. The ultimate scope is to dissect related cellular, molecular and/or epigenetic pathways and to uncover relevant drug targets.
Yeast cultures under sterile conditions, microscopy, drug dose-response curves, determination of minimum inhibitory concentration (MIC); cell proliferation, survival, staining; evaluation of cell morphology and reproduction.
Preliminary readings, literature search & journal clubs will be provided.
Yeast cultures under sterile conditions, microscopy, cell staining, MIC determination, growth curves, drug dose-response curves.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Participate in the molecular lab work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
For the use of students considering participating in the project, further information can be found in : www.med.uoa.gr/pharmacology/en/faculty/tiligada/index.html
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Bitterman KJ Medvedik O Sinclair DA. (2003) Microbiol Mol Biol Rev 67:376-99
- Longo VD Shadel GS Kaeberlein M Kennedy B. (2012) Cell Metab 16:18-31
- Wasko BM Kaeberlein M. (2014) FEMS Yeast Res 14(1):148-59
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