Modifying the anticonvulsive activity of antiepileptic drugs by gap-junction blockers.
Poland (IFMSA-Poland) - Medical University of Lublin, Lublin
Department of Patophysiology, Medical University, Jaczewskiego 8, 20-090, Lublin, Poland
Prof. Stanislaw J. Czuczwar, M.D., Ph.D
Prof. Stanislaw J. Czuczwar, M.D., Ph.D
English, Russian
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
Gap-junction blockers can induce anticonvulsant effects per se. It may be a novel group of agents considered for the treatment of epilepsy. The research can help in gaining new information on this particular topic.
What is the aim of the project?
A question arises whether gap-junction blockers can enhance (in subprotective poses) the anticonvulsant activity of a number of antiepileptic drugs.
What techniques and methods are used?
Maximal electroshock-induced seizures in mice; Chimney test; Passive avoidance task; Estimation of brain contentration of antiepileptic drugs by HPLC and immunoassay.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No particular skills.
Are there any legal limitations in the student’s involvement
One legal limitation is that the student is not allowed to touch the experimental animals.
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
- Lason et al. Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamics interactions- an update. Pharmacol. Rep 2011; 63:271-292