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Evaluation of the role of synthetic neurosteroids on psoriasis
Greece (HelMSIC) - University of Crete, Heraklion
Department of Clinical Chemistry, Medical School, University of Crete, Greece
Type of Research Project
- Basic science
What is the background of the project?
Psoriasis is a chronic inflammatory autoimmune skin disease that affects 2-3% of the Caucasian population. The pathogenesis of psoriasis remains largely unknown and is most likely a complex, multifactorial process. Clinical observations have suggested that the nervous system is involved in the disease process through neuropeptides and neurosteroids. Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties. DHEA has been suggested to participate in physiological and pathophysiological conditions of the skin. Its synthetic analogue, synthetic microneurotrophin BNN27 which cannot be converted to estrogen or androgen as DHEA, seems to conserve the immunomodulatory properties of DHEA when used in an in vivo animal model of multiple sclerosis and LPS-induced brain inflammation. Based on the above, our proposal aims to test the hypothesis that BNN27 exerts immunomodulatory effects on skin inflammatory models, such as psoriasis in mice.
The aims of the project are: (a) evaluate the effect of BNN27 on the development and progress of psoriasis in vivo using a drug-induced psoriasis animal model and (b) try to identify the target skin cell population(s) which mediate the effect of BNN27.
Teqniques such as: Animal handling, Induction of psoriasis in mice, RNA and protein extraction, RT-PCR, Real Time PCR, Western blot, ELISA, Immunocytochemistry, will be used.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Participate in the Lab Work of the Project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skills are required and there are no legal limitations in the student
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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