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The role of Chromogranin?A (CgA) in Monitoring Patients with inflammatory bowel diseases
Greece (HelMSIC) - Democritus University of Thrace, Alexandroupoli
Biophysics and Medical Physics
Nuclear Medicine Department, Democritus University of Thrace, University Hospital of Alex
Dr. Athanasios Zissimopoulos Asoc. Prof. of Nuclear Medicine
Dr. Athanasios Zissimopoulos, Evangelos Karathanos physician of Nuclear Medicine
English, German, French
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Chromogranin A (CGA) is a 439-amini acid protein with a molecular weight of 48 to 60 kDa, depending on glycosylation and phosphorylation status. It is a member of the granin family of proteins and polypeptides. Granins are widespread?in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are found in secretory granules alongside the tissue-specific secretion products. There seems to be a relationship between the enteric nervous system and the immune system in the pathophysiology of inflammatory bowel disease - patients with collagenous colitis had elevated fecal Chromogranin A, fecal Chromogranin B and fecal secretoneurin compared to normal controls and inflammatory bowel disease, while patients with inflammatory bowel disease had markedly lower levels of fecal secretoneurin than normal controls The purpose of this project is to investigate the possible relation between varying levels of chromogranin A in the blood and various phases of Crohn's disease, diarrhea syndromes and ulcerative colitis. What techniques and methods will be used? 1) Serum CgA measurements by Radioimunoassay Method (RIA) in the laboratory of Nuclear Medicine Dept. with commercial kits. 2) Whole body bone scans with 925 MBq 99mTc-MDP using tomographic gamma- Camera (GE Millennium MPR, MPS U.S.A) Lectures and seminars will be provided.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Legal limitations: PREGNANT WOMEN. No special skills are required.
1. Bartolomucci A, Possenti R, Mahata SK, et al (2011), The extended granin family: Structure, function and biomedical implications, Endocr Rev 2011:32:755-97)
2. Glinicki P, Jeske W, (2011), Chromogranin A (CgA)- the influence of various factors in vivo and in vitro, and existing disorders on it's concentration in blood, Klinika
Endokrynologii, Centrum Medyczne Ksztalcenia Podyplomowego w Warszawie, 62 Suppl 1:25-8
3.Pirker RA, Pont J, Pohnl R, Schutz W, Griesmacer A, Muller MM, (1998), Usefulness of chromgranin A as a marker for detection of relapses of carcinoid tumors, Institute of Laboratory Diagnostics, Kaiser Franz Josef- Hospital ViennAustria, 36(11):837-40.
4. El Salhy M, Gundersen D, Hatlebakk JG, Hausken T, (2012), Chromogranin A cell density as a diagnostic marker for lymphocytik coliis, Section forGastroenterology,
Department of Medicine, Stord Helse-Fonna Hospital, 57
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- The extended granin family: Structure function and biomedical implications ( Endocr Rev 2011:32:755-97) Bartolomucci A. Possenti R. Mahata SK. et al (2011)
- Glinicki P. Jeske W. (2011) Chromogranin A (CgA)- the influence of various factors in vivo and in vitro and existing disorders on it's concentration in blood. Klinika Endokrynologii Centrum Medyczne Ksztalcenia Podyplomowego w Warszawie 62 Suppl 1:25-8.
- Pirker RA. Pont J. Pohnl R. Schutz W. Griesmacer A. Muller MM. (1998) Usefulness of chromgranin A as a marker for detection of relapses of carcinoid tumors. Institute of Laboratory Diagnostics Kaiser Franz Josef- Hospital ViennAustria 36(11):837-40.
- El Salhy M. Gundersen D. Hatlebakk JG. Hausken T. (2012) Chromogranin A cell density as a diagnostic marker for lymphocytik coliis. Section forGastroenterology Department of Medicine Stord Helse-Fonna Hospital 57
- Sciola V. Massironi S. Conte D. Caprioli F. Ferrero S. Ciafardini C. Peracchi M. Bardella MT. Piodi L. (2009) Plasma chromogranin A in patients with inflammatory bowel disease . Gastroenterology Unit II . Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena. University of Milan. Milan Italy 15(6):867-
- Malaty HM
- Hou JK
- Thirumurthi S. Epidemiology of inflammatory bowel disease among an indigent multi-ethnic population in the Unitated States. Department of edicine
- Baylor College of Medicine
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