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Detection of membrane androgen receptors in prostate cancer
Greece (HelMSIC) - University of Crete, Heraklion
Laboratory of Experimental Endocrinology School of Medicine, University of Crete
Type of Research Project
- Basic science
What is the background of the project?
Prostate cancer is the most common malignancy in males and the second most common death cause
Hormonal (androgen deprivation) therapy is the cornerstone of prostate cancer treatment. However, the major therapeutic challenge in prostate cancer therapy is the inevitable development of hormonal resistance. A better understanding of the actions of androgens is essential for potential novel efficient therapies. During the last decade, our knowledge on androgens has been greatly advanced with the discovery of membrane initiated actions that can greatly affect prostate cancer cell fate, independent of the presence of the classical intracellular receptor. Therefore membrane androgen receptors could possibly play an important role in prostate cancer development/progression as well as in endocrine therapy.
The aim is to detect membrane androgen receptors in prostate cancer, compare different detection methods and explore their role in cancer progression.
Techniques and methods such as Cell culturing , Immunocytochemistry, Microscopy, Flow cytometry will be used.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Based on the Supervisor's instructions anything from Lab Work to data analysis
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, if needed
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic Lab Science Skills_and Basic knowledge of Cell Biology. No legal limitations.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Membrane steroid receptor signaling in normal and neoplastic cells. Mol Cell Endocrinol. 2006 Feb 26;246(1-2)76-82.
- Androgen receptors in early and castration resistant prostate cancer friend or foe Hormones (Athens). 2013 Apr-Jun12(2)224-35
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