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Study of craving and impulsivity in alcohol use disorder
Spain (IFMSA-SPAIN)-University of Cadiz, Cadiz
Neurosciences department of University of Cadiz and ARCA association
Juan Manuel Ignacio Garcia
Yaiza Cabrera and Juan Gibert Rahola
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Alcohol use disorders (AUD) continue to be a concerning health issue worldwide. Harmful alcohol use leads to 2.5 million deaths annually worldwide. Multiple options exist for the management of dependence on alcohol, not all of which are approved by drug-regulating agencies. Current practice in treating AUD does not reflect the diversity of pharmacologic options that have potential to provide benefit, and guidance for clinicians is limited. Few medications are approved for treatment of AUD, and these have exhibited small and/or inconsistent effects in broad patient populations with diverse drinking patterns. The need for continued research into the treatment of this disease is evident in order to provide patients with more specific and effective options. This review describes the neurobiological mechanisms of AUD that are amenable to treatment and drug therapies that target pathophysiological conditions of AUD to reduce drinking. In addition, current literature on pharmacologic (both approved and non-approved) treatment options for AUD offered in the United States and elsewhere are reviewed. The aim is to inform clinicians regarding the options for alcohol abuse treatment, keeping in mind that not all treatments are completely successful in reducing craving or heavy drinking or increasing abstinence. Craving and impulsivity are the two main characteristics in people who have a alcohol use disorder and they can determine the dependence and tolerance to this drug. Furthermore, according to the intensity of craving or type of impulsivity, treatment with nalmefene or topiramate or both will be proposed.
What is the aim of the project?
Study the existence and intensity of craving as well as the characteristics and types of impulsivity in patients with alcohol use disorders.
What techniques and methods are used?
Clinical and epidemiological work. Use of different questionaires (EMCA for the craving , EIE for impylsivity, Millon, MINI, SF36, ASRSv1)
What is the role of the student?
- The tasks will be done under supervision
- If the project is clinical
- the student will be allowed to work with patients
What are the tasks expected to be accomplished by the student?
The student will participate in the epidemiological study that is being conducted to determine the characteristics of craving and impulsivity in outpatients attending ARCA to be treated for alcohol use disorder. Treatment depends on the nature and intensity of these two factors. The student will learn the basics of alcohol use disorders, diagnosis, the use of different questionaires (EMCA for the craving , EIE for impylsivity, Millon, MINI, SF36, ASRSv1) different psychological and pharmacological treatments and how it should be addressed to families.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have studied Psychology and Psychiatry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Wackernah RC; Minnick MJ; Clapp P. Alcohol use disorder: pathophysiology; effects; and pharmacologic options for treatment. Subst Abuse Rehabil. 2014 Jan 23;5:1-12.
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