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Investigation of brain development using advanced optical microscopy
Taiwan (FMS-Taiwan) - National Yang Ming University, Taipei
Institute of Brain Science, National Yang-Ming University
Yung-Yang-Lin, M.D., Ph.D., Professor
Jin-Wu Tsai, Ph.D., Assistant Professor
Type of Research Project
- Basic science
What is the background of the project?
Brain is the most remarkable structure underlying the profound computational capabilities of the human being. development of the brain involves numerous tightly controlled genes and cellular events. Mutations of these genes that cause even tiny perturbation during brain development could cause big effects, such as malformation of brain structures, abnormal neuronal activities, and even premature death. Although a lot of genes are known to play essential roles in this complex process, many more genes have yet been identified. Moreover, the cellular and molecular functions of these genes are still not fully understood. This line of research also sheds lights on molecular etiology of brain developmental disorders in human and may provide potential new therapeutic strategies for these and related disorders.
What is the aim of the project?
This project aims to search for new mutations that cause brain developmental disorders, by analyzing human patients and transgenic mouse models. We will investigate the cellular and molecular functions of these genes in the nervous system during development and dissect the etiology of these disorders. We will also look for potential treatments that could reverse the defects caused by these mutations.
What techniques and methods are used?
What techniques and methods will be used? We will use basic genetic, biochemical, and molecular biological approaches to analyze these genes, such as genetic screening, molecular cloning, protein analysis, RNA interference, etc. We will also use advanced microscopy techniques to dissect the function of these genes, such as fluorescence microscopy, confocal micrscopy and twophoton microscopy. Our lab is equipped with all necessary equipments for these studies. Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)? Yes. We will have courses on microscopy and brain development. Literature in the related field will also be assigned to catch up with recent progress.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will learn new techniques from the laboratory and (hopefully) enjoy the process of scientific discoveries. When performing experiments, the student is expected to follow the lab safety rules. If animal handling is needed for the project, the student is required to complete the animal handling training and follow all rules and protocols established by the Institutional Animal Care and Use Committee (IACUC). When the student is not in the lab, trying as many different Taiwanese cuisines is highly recommended.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic concepts on biology, chemistry, or physics are required. Experience in hands-on laboratory work is preferred. Dare to try all kinds of food is a must. For more information, please go to: http://bml.ym.edu.tw/ibs/brain/TsaiLab/
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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