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Cellular electrophysiology of the heart
Czech Republic (IFMSA CZ) - Charles University in Plzen, Plzen
Dept of Physiology, Faculty of Medicine in Pilsen, Charles University,
doc. MUDr. Milan Stengl, Ph.D.
doc. Sviglerova, doc. Kuncova, doc. Chottova-Dvorakova, dr. Nalos, Ing. Jarkovska,...
Type of Research Project
- Basic science
What is the background of the project?
Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e.g. electrophysiological, contractile remodeling) changes. The remodeling is initially compensatory and beneficial optimizing the pumping function but gradually it may become detrimental (heart failure, life-threatening arrhythmias). These changes of the myocardium in various diseases (e.g. sepsis) are studied in the department and various aspects of cardiovascular physiology will be introduced to students.
What is the aim of the project?
To study the cardiac remodeling in various experimental conditions and to introduce the methods to students.
What techniques and methods are used?
Cardiac experimental electrophysiology from in vivo to cellular (ECG, sharp glass microelectrodes, patch-clamp), mitochondrial physiology (ultrasensitive oxygraphy), mRNA expression.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
For the use of students considering participating in the project, further information can be found from the following articles: <br>Stengl M, Ledvinova L, Chvojka J, Benes J, Jarkovska D, Holas J, Soukup P, Sviglerov&#225; J, Matejovic M. Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study. Crit Care 2013; 17:R303 <br>Sviglerova J, Kuncova J, Stengl M. Cardiovascular models: Heart secondarily affected by disease.In: Animal models for the study of human disease, Ed. Conn PM, Elsevier Academic Press 2013. <br>Sv&#237;glerov&#225; J, Kuncov&#225; J, Nalos L, Holas J, Tonar Z, Rajdl D, Stengl M. Cardiac remodeling in rats with renal failure shows interventricular differences. Exp Biol Med 2012; 237:1056-67 <br>Stengl M, Bartak F, Sykora R, Chvojka J, Benes J, Krouzecky A, Novak I, Sviglerova J, Kuncova J, Matejovic M. Reduced L-type calcium current in ventricular myocytes from pigs with hyperdynamic septic shock. Crit Care Med 2010; 38:579-87
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skills are required, the students should be familiar with basic principles of biology and/or preclinical medicine.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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