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Investigations of changes in neurotransmitter receptors and plasticity-related proteins in an animal model of Alzheimer
Germany (bvmd) - Ruhr-Universitaet, Bochum
Ruhr University Bochum Department of Neurophysiology, Universitaetsstr. 150, MA4/150, 4478
Prof Dr. Denise Manahan-Vaughan
Prof Dr. Denise Manahan-Vaughan (LMR@rub.de)
Type of Research Project
- Basic science
What is the background of the project?
Synaptic plasticity is a cellular process through which neuronal communication becomes altered such that information can be stored at the synapse level. It is the core mechanism that underlies short-and long-term memory in the brain. The hippocampus is profoundly compromised in Alzheimer
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Fluent spoken and written english
Interest in, and willingness to, work with research animals
Very good basic understanding of the neurophysiological and biochemical basis of cognition and memory formation in the brain
An understanding of the current understanding of the pathophysiology of AD on a cellular level.
Have completed the first 4 semesters (2 years) of their medical degree studies More information can be found here:
Kemp A, Manahan-Vaughan D (2007) Hippocampal long-term depression: master or minion of declarative memory processes. Trends Neurosci. 30: 111-118.
Masters CL, Selkoe DJ. (2012) Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med. 2:a006262.
Mucke L, Selkoe DJ. (2012) Neurotoxicity of amyloid β-protein: synaptic and netw
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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