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New strategies for diagnostic, therapeutic and clinical care in infection and immunity
Universita degli Studi di Foggia
Dept. of Medical and Surgical Sicences - Nephrology
Prof. Maria Pia Foschino
Prof. Elena Ranieri, Prof. Giuseppe Stefano Netti
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Sepsis has been well recognized as a systemic inflammatory response to an active infectious process in the host. Sepsis is the leading cause of death and acute kidney injury (AKI) in critically ill patients. A large body of evidence suggest that sepsis-associated AKI is due to tissue hypoperfusion,a chemically/biologically mediated injury on resident kidney cells. A broad range of mediators produced by inflammatory cells have been identified as responsible for sepsis-related tissue injury. Numerous clinical studies have been performed to tackle the problem of mediator removal and modulation of the unbalanced inflammatory response. Extracorporeal elimination techniques have been proposed as a possible approach for cytokine elimination to improve the clinical conditions of septic patients.
What is the aim of the project?
Aim 1: To explore new pathogenic mechanisms of sepsis-induced AKI, with special regard to the role of soluble/cellular components of innate immunity, focusing on activation of Complement system and dendritic cells. Aim 2: To identify new therapeutic approaches by exploring the ability of extracorporeal treatments to interfere with the pathogenic mediators of sepsis-induced AKI identified in aim 1. Aim 3: To define early and reliable biomarkers for risk assessment, diagnosis, prognosis, and response to therapy in sepsis-related AKI.
What techniques and methods are used?
We will analyze biological samples from animal models. Classical renal microscopy and immunohistochemistry, molecular biology methods, as well as systems biology approaches (genomic/proteomic/metabolomic analyses) will be used.The entire transcriptome and its miRNAome will be analysed. Classical proteomic approaches will be combined with advanced mass spectrometric techniques; NMR analyses will be carried out for metabolomics. Cell cultures, Western Blot analysis, cell survival/death assays, immunoprecipitations and co-immunoprecipitations, and ELISA determinations will be also used. Bioinformatic analyses and computational biology methods will be used.
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
he student will have a role as participant in all the technical phases concerning the project. In particular the student will participate in planning experiments and in evaluating the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have a basic knowledge in biological sciences and/or biotechnologies. There are not legal limitations in the student
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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