Projects
Name
Research on prognostic and predictive biomarkers for breast cancer and colorectal cancer
University
the Netherlands (IFMSA-NL) - University of Leiden, Leiden
Domain
General Surgery
Departement
Dept. of Surgery, Surgical Oncology Research Lab
Head
Dr. P.J.K. Kuppen
Tutor
Dr. P.J.K. Kuppen and PhD students and technicians in the lab
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The Surgical Oncology research program from the Department of Surgery consists of translational research with a focus on colorectal, breast and upper gastro-intestinal tract tumors. The purpose of the research is to determine tumor-related parameters that may enable 'tailored treatment' by identifying high-risk patients for tumor recurrence. Furthermore, research is focused on improvement of surgical treatment methods, especially by development of near-infrared image-guided surgery. The aim of the project is to find tumor-associated parameters at the level of DNA/RNA/protein that have clinical prognostic or predictive value. Furthermore, targets and probes are studied for the development of image-guided surgery. Research is performed in large panels of primary tumors of patients with known clinical follow-up. The most important techniques that will be used are immunohistochemistry and statistical analysis to relate tumor-associated parameters to clinicopathological data. The student is expected to read literature on the specific subject of his/her project. The student is expected to be highly motivated for the research project and to show an attitude of activate participation and initiative. The student will be supervised on all techniques applied in the project and is expected to be able to work independently after a training period. The outcome of the student's participation in the research project should be a report in English language. During the exchange program the student will learn how to apply immunohistochemistry and relate findings to clinical outcome using statistical analysis. Furthermore, he/she will learn more about breast and colorectal cancer in general.
What is the aim of the project?
The aim of the project is to find tumor-associated parameters at the level of DNA/RNA/protein that have clinical prognostic or predictive value. Furthermore, targets and probes are studied for the development of image-guided surgery.
What techniques and methods are used?
Research is performed in large panels of primary tumors of patients with known clinical follow-up. The most important techniques that will be used are immunohistochemistry and statistical analysis to relate tumor-associated parameters to clinicopathological data.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to be highly motivated for the research project and to show an attitude of activate participation and initiative. The student will be supervised on all techniques applied in the project and is expected to be able to work independently after a training period.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Only students who finished at least their first two years of medicine, biomedical sciences, or a related study will be considered for a project. Communication in English must be sufficient. For the use of students considering participating in the project, further information can be found from the following articles: https://www.lumc.nl/research/programmes/80304013111221/80225015645221/ Medical students and students in biomedical fields will be accepted to the project. The minimum duration of the research exchange period is 4 weeks, but preferably longer. There are approximately 8 hours of work per day We can accept 4 students per year and 2 students at the same time per one exchange period
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
Articles
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