Genetic analyses in multifactorial diseases (e.g., multiple sclerosis, allergic diseases)
Germany (bvmd) - Ruhr-Universitaet, Bochum
Department of Human Genetics, Ruhr-University Bochum, Universitätsstr. 150, 44801
Prof. Dr. Joerg T. Epplen
Dr. Sabine Hoffjan (
6 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Basic science
What is the background of the project?
Multifactorial diseases such as multiple sclerosis or allergic diseases are caused by complex interaction between genetic predisposition and environmental factors. Through comparison of genetic polymorphisms in cohorts of affected individuals and healthy controls, we aim at elucidating the genetic background of multifactorial disorders. The specific content of a certain project will be chosen shortly before the start of the research period in order to investigate topics that are of special interest at that time.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
journal club reading
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Some kind of lab skills would be preferable, but are not absolutely necessary
For further information please look for:
The genetics of multiple sclerosis: an update 2010. Hoffjan S, Akkad DA. Mol Cell Probes. 2010 Oct;24(5):237-43.
Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort. Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. BMC Dermatol. 2014 Nov 3;14(1):17.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
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