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[Zacatecas] Rosmarinus officinalis (rosemary) as adjunctive therapy for patients with Diabetes Mellitus 2: effect on oxidative stress, insulin resistance.
Universidad Autonoma de Zacatecas
Doctoral Program in Molecular and Medical Pharmacology Universidad Aut&#243;noma de Za
Dr. en C. Juan Carlos Medrano
Dra. En C. Claudia Araceli Reyes Estrada
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Type 2 Diabetes Mellitus is a chronic degenerative disease with several degrees of genetic predisposition and environmental factors. It is a disease that is considered a public health problem worldwide. In T2d, cell damage occurs, especially at the level of cellular proteins, carbohydrates, lipids and DNA. The disease presents complications associated with an increased Oxidative Stress and insulin resistance, dependent on the participation of different genes. Recently the use of alternative plants for the treatment of various diseases such as diabetes and within the plants which have been attributed with a high antioxidant activity. Rosemary (Rosmarinus officinalis) is therapy, for that we propose to determine if dietary rosemary tea for T2D individuals decreases the DNA damage represented by the decrease in the number of micronucleus, and decrease of OxS and glucose levels.
What is the aim of the project?
The objective of the project is determine the effects of Rosmarinus officinalis extracts (Rosemary) on oxidative stress, insulin resistance, DNA damage and microRNAs in patients with type 2 diabetes for use as adjunctive therapy.
What techniques and methods are used?
Extractions tests oxidative stress tests (PLT, GPX) Qualitative and quantitative chemical analysis.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
- The student may perform the sampling of patients in the hospital - process extracts and reagents in the laboratory with certain procedures. The student will use all laboratory equipment required for the project under supervision of tutor.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in medicine and basic laboratory skills.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Erkan N; Ayranci G and Ayranci E. 2008. Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract; blackssed (Nigella sativa L) essential oil; carnosic acid; rosmarinic acid and sesamol. Food Chem. 110: 76-82
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