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Genetic studies of large consanguineous pedigrees with major psychiatric disorders from Pakistan
Laboratory of Neurogenetics, Research Centre, Montreal Mental Health University Institute,
Lan Xiong, PhD
Qin He, Amelie Johnson
English or French
Type of Research Project
- Basic science
What is the background of the project?
Pakistan has the highest rate of endogamous consanguineous marriage in the world. The potential influence of such a long history of consanguineous unions on overall levels of homozygosity genome-wide and on genetic disease profiles remains largely under-investigated, especially for more common and complex diseases. Schizophrenia (SCZ) and bipolar (BP) disorders, and the intermediate phenotype of schizoaffective disorder (SAF), are common brain diseases in all populations with largely unknown etiology and molecular pathogenic pathways. Genetic factors have been considered as important contributing causes and have been the focus of intensive research efforts in the past decades. Rapidly developing massive parallel genotyping and sequencing technologies have now provided us with efficient and increasingly affordable solution to identify all genetic risks in targeted individual, family and community genomes.
What is the aim of the project?
To identify genetic risk factors in large consanguineous pedigrees with major psychiatric disorders such as schizophrenia (SCZ) and bipolar (BP) disorders, and the intermediate phenotype of schizoaffective disorder (SAF) in Pakistan
What techniques and methods are used?
SNP genotyping, Sanger sequencing, next generation sequencing, DNA microarrays, bioinformatics and statistical analyses.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will participate in ongoing research projects in the lab and collaborate with lab members, will be provided with training on techniques and methods, then perform certain research activities common in the field of psychiatry under supervision.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, we will provide reading materials, organize weekly lecture and monthly seminar.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student is expected to have some basic knowledge in molecular biology, human genetics and informatics. The student may start and end on any day that they wish, provided they respect the 4 weeks requirement of the exchange and the 80% attendance rate as stated by SCORE exchange programs.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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