Projects
Name
The role of intestinal microflora in non-alcoholic fatty liver disease (NAFLD)
University
Catalonia (AECS) - University of Girona (UdG), Girona
Domain
Endocrinology
Departement
Section of Diabetes, Endocrinology and Nutrition
Head
Jose Manuel Fernandez-Real, M.D., Ph.D.
Tutor
Jose Maria Moreno / Paco Ortega
Languages
English (Spanish not mandatory but desired)
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Constitution of the cohorts: identifying patients with various degrees of Non-Alcoholic Fatty Liver Disease, obesity and insulin resistance and collect biological samples (urine, faeces and blood) which will be the basic material for the identification of markers.
The student will work on tissue and sample collection for the determination of parameters linked with non alcoholic liver fatty disease
The general objective is to increase, disseminate, and gain new knowledge about the biological processes and mechanisms which are responsible for the development of Non-Alcoholic Fatty Liver Disease which is an increasingly important source of morbidity in western populations. The results of the project will provide a cohort of patients well characterized with respect to the severity of the Non-Alcoholic Fatty Liver Disease, their insulin sensitivity and obesity.
The student will help in the process of chosing the cohort: clinical characterization, oral glucose tolerance test, intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp, evaluation of body composition using bioimpedance, hepatic ecography and collection of blood, urine and faeces.
What is the aim of the project?
The general objective is to increase, disseminate, and gain new knowledge about the biological processes and mechanisms which are responsible for the development of Non-Alcoholic Fatty Liver Disease which is an increasingly important source of morbidity in western populations. The results of the project will provide a cohort of patients well characterized with respect to the severity of the Non-Alcoholic Fatty Liver Disease, their insulin sensitivity and obesity.
What techniques and methods are used?
The student will help in the process of chosing the cohort: clinical characterization, oral glucose tolerance test, intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp, evaluation of body composition using bioimpedance, hepatic ecography and collection of blood, urine and faeces.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student during the exchange will expected to be to learn different laboratory techniques. To carry out a part of the research activities from the group being supervised by a tutor. We expect dedication and collaboration from the student, and to be interested in the research project.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will have to assist at seminars and lectures done during the exchange perdiod at the department. Scientific literature reading will be required and also the discussion of the results with the research team.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The exchange student should have a theoretical background like basic laboratory techniques and analysis. The student should have contracted an insurance policy covering potential lab-related accidents.
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
- Students in biomedical fields
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/20379797
- http://www.ncbi.nlm.nih.gov/pubmed/16033867