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Study of control of dendritic cell development and functions
Taiwan (FMS-Taiwan) - National Taiwan University, Taipei
Graduate Institute of Immunology
Prof. Chien-Kuo Lee
Type of Research Project
- Basic science
What is the background of the project?
Dendritic cells (DCs) are the most important antigen presenting cells and modulators for innate and adaptive immunity. In fact, this is the main reason why Dr. Ralph Steinman, who discovered DCs, received the Nobel Prize in 2011. However, homeostasis of DCs during steady-state and during infection or inflammation remains elusive.
What is the aim of the project?
The aim of this project is to study regulation of DC development and functions at steady state and during inflammation on DC development. This study may facilitate vaccine designs and tumor therapy.
What techniques and methods are used?
1. Reverse transcription-quantitative PCR (RT-QPCR) 2. Flow cytometry 3. Animal handling 4. Tissue culture 5. Lentiviral transduction and stable cell clone selection
What is the role of the student?
- The tasks will be done under supervision
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
1. Lean to design and conduct experiments 2. Present the works at the end of exchange 3. Interact with the lab members 4. Learn knowledge concerning dendritic cells 5. Language and culture exchange
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, there will be five lectures on introduction to immunology and immunological methods. Plus, there will be weekly lab meetings to introduce the research projects in the lab.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special knowledge is required. However, basic knowledge in biochemistry, molecular biology and biology will help understand the basis of some experiments. 1. For the use of students considering participating in the project, further information can be found from the following articles: The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting. Annual Review of Immunology 2013 Vol. 31: 563-604 2. http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/popularmedicineprize2011.pdf 3. http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/advancedmedicineprize2011.pdf minimum duration: 4 weeks maximum duration: 8 weeks There are approximately 6-8 hours of work per day.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- A type I IFN/Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. JEM 2013 210:2515-2522
- Yi-Ling Chen; Shiun Chang; Ting-Ting Chen and Chien-Kuo Lee 2015 Efficient generation of plasmacytoid dendritic cell from common lymphoid progenitors by Flt3 ligand. PLoS One 10(8): e0135217 DOI:10.1371/journal.pone.0135217
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