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Investigation and characterization of a Caldesmon deficient mouse
Germany (bvmd) - Universitaet zu Koeln, Cologne
Institute of Vegetative Physiology
Prof. Dr. Gabriele Pfitzer
Dr. L. Lubomirov, Dr. M. Schroeter
Type of Research Project
- Basic science
What is the background of the project?
The actin and myosin binding protein caldesmon is found to be ubiquitously expressed. Different domains of the protein were mapped and associated with the regulation of the contractile machinery, suggesting a vital function of the protein. The ablation of single domains was compatible with life. We now ablated total caldesmon in mice and found the animals to be lethal.
The protein caldesmon is known for more than 30 years and was the subject of multiple investigations. Most of these studies were carried out in in vitro, so its physiological function is still not well understood. The ablation of the total protein in mice enables us now to use different approaches to illuminate its function in vivo. These functions may well project beyond regulation of contractility and may even involve control of the transcriptional machinery.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The main requirements are enthusiasm and a high frustration threshold, since many experiments work only the first time and then stop working or they work after a long trail and error phase where every single aspect has been checked.
Puetz, Lubomirov, Pfitzer (2010) Regulation of Smooth Muscle Contraction by Small GTPases. Physiology 24: 342-356
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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