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Genetics in neurological diseases (Parkinson s disease and multiple sclerosis)
Greece (HelMSIC) - University of Thessaly, Larissa
Neurogenetic Department, Faculty of Medicine, University of Thessaly, Biopolis, Larissa
Georgios. M. Hadjigeorgiou
Type of Research Project
- Basic science
What is the background of the project?
Although the cause of multiple sclerosis (MS) is unknown, variations in dozen of genes are thought to be involved in MS risk. Especially, the HLA-DRB1 gene of the human leukocyte antigen (HLA) family. For Parkinson's disease, a progressive disorder of the CNS, several gene mutations have been discovered, including PINK1, LRRK2 or SNCA gene as well as alterations in genes that play role in dopamine release. The project aims to detect genetic polymorphisms responsible for neurological diseases like multiple sclerosis, parkinson's disease etc. and their effects on the severity of the symptoms observed on the aforementioned diseases. Techniques that will be used include DNA isolation, polymerase chain reaction (PCR), RFLP, fragment analysis, sequencing.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must be very careful with the material because there are very sensitive and to act exactly as instructed. Success in basic preclinical courses (Cell Biology, Physiology) is evaluated positively.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Sharma M et al; On behalf of the GEO-PD Consortium. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology 2012;79(7):659-667
- Xiromerisiou G. Hadjigeorgiou GM. Eerola J. Fernandez HH. Tsimourtou V. Mandel R.
- Elbaz A. Nelson LM. Payami H. Ioannidis JP. Fiske BK. Annesi G. Trikalinos TA. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol. 2006 Nov 5(11) : 917-23
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