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Role of apolipoprotein D in the demyelination and remyelination processes: implications in multiple sclerosis
Spain (IFMSA-SPAIN) - University of Oviedo, Oviedo
Morphology and Cell Biology Department
Jose Antonio Vega Alvarez
Ana Maria Navarro Incio and Eva del Valle Suarez
English or Spanish or Italian
Type of Research Project
- Basic science
What is the background of the project?
Apolipoprotein D (Apo D) is a lipocalin with several functions, standing out its role as membrane protector against oxidative stress; moreover it is one of the most overexpressed molecules in nerve repair processes, being considered necessary for a correct remyelination. It is known e Apo d is expressed in Schwann cells and oligodendrocytes together with a group of proteins of paramount importance for the synthesis and formation of the myelin sheath.
Based on the lack of previous studies in the CNS, it is necessary to deepen in the role of Apo D in the demyelination and remyelination processes in this area. For this purpose, we consider very useful to use multiple sclerosis (MS) as a model for these phenomena.
The study will be addressed at three levels: studies of human samples with MS; in vitro, in oligodendrocytes cultures, and in vivo in an animal model of MS already established and based on cuprizone as a demyelinating agent.
Techniques: cell culture, histochemistry, immunohistochemistry, Western blot
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic lab skills are requiered and it would be desireable that the student had coursed basic subjects as Cell Biology, Histology and Biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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