The study of the mechanism of thoracic aortic aneurysm formation due to regulatory changes in TGF-1B signal pathway
University of Pavol Jozef Safarik
Department of Medical and Clinical Biochemistry, UPJS in Kosice, Faculty of Medic
prof. Ing. M. Marekova, CSc.
RNDr. Miroslava Bilecova-Rabajdova, PhD. ; Mgr. Peter Urban, PhD.
English, Polish, Russian
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
Genetic variability and changes in specific genes expression (e.g. emilin-1, fibrillin, TGF-1B receptors and metalloproteinase) critically affect the development of thoracic aorta aneurysm (TAA). We would like to contribute to better understanding of the mechanism of TGF-1B inhibition and activation depending on the level of damage in thoracic aortal wall. New information gained in solving the project will contribute to more detailed elucidation of the development and progression of pathological changes in patients with TAA and to
better understanding of signal pathway of TGF-1B activation or inhibition.
Obtained knowledge can give the basis for a new therapeutic approaches aimed precisely to inhibit degradation processes in vascular tissue and progression of TAA development.
What is the aim of the project?
The aim of this project is to study the mechanism of thoracic aneurysm formation due to regulatory changes in TGF-1B signal pathway with following correlation of aortic wall damage and size of the aortic aneurysm.
What techniques and methods are used?
Isolation of Nucleic acids, proteins, Polymerase chain reaction techniques, Western-Blot
What is the role of the student?
What are the tasks expected to be accomplished by the student?
will to work in a lab
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It would be useful if students has already studied biochemistry and have an interest in studying Clinical Biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- a:0:{}