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[Saltillo] Evaluation of the role of Th17 cells in the protective effect of different vaccines against M.tuberculosis
Universidad Autonoma de Coahuila
Health Investigation Center
Dr. Ana Cecilia Cepeda Nieto
Sandra Cecilia Esparza Gonzalez
Type of Research Project
- Basic science
What is the background of the project?
Tuberculosis is the second infectious that causes the biggest mortality in the world. The World Health Organization estimates 80 million new cases of tuberculosis in this decade. Particularly Mexico is considered an endemic area. The epidemiological surveillance center reports approximately 20,000 new cases of tuberculosis each year that gives approximately 6,000 deaths. This number has increased with the advent of HIV and the emergence of new cases reporting resistance to first-line drugs such as isoniazid and rifampicin. Due to this problem the WHO declared a state of reemergence of the disease. Therefore investigations worldwide have focused on developing new tools that allow us to prevent, control and eliminate the infection.
What is the aim of the project?
The aim of the project is to determine the involvement of Th17 cells in effective vaccines against M. tuberculosis infection.
What techniques and methods are used?
- RNA extraction - Cell culture techniques - Detection of cytokines like interleukins, IFN-gamma and TNF-alpha using ELISA
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge in the area of microbiology and knowledge on the handling of basic equipment of a laboratory.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Schluger; N. The pathogenesis of tuberculosis: the first one hundred (and twentythree) years. Am J Respir Cell Mol Biol 32; 251-256 (2005).
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