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Modulation of mast cell responses by members of CD150 and CD300 family of receptors and associated molecules. New targets in mast cell-derived pathologies.
Catalonia (AECS) - University of Barcelona (UB) - Hospital Clinic, Barcelona
Biochemistry and Molecular Biology Unit. Faculty of Medicine.
Arcadi Gual Sala
Margarita Martin Andorra
English and Spanish
Type of Research Project
- Basic science
What is the background of the project?
Mast cells are currently recognized as effector cells in many settings other than mere allergic reactions, including innate immunity, autoimmunity, chronic inflammatory disorders and atherosclerosis. Recent observations show that appropriate activation and fine tunning of mast cell responses is mediated by a complex array of factors including IgE receptor, kinases/phosphatases, adaptor molecules, and various classes of co-stimulatory molecules that modulate their function. These molecules may therefore contribute to the outcome of mast cell-associated pathologies, and may constitute new therapeutic targets in such diseases. Data from our group show that CD84 receptor negatively regulates IgE receptor. Furthermore, CD84, CD150, CD300a and CD300f receptor expression are differentially modulated after human mast cell activation suggesting a role as new targets in pathology.
The aim of the project is to understand how mast cell responses are regulated. Deepen in the knowledge of mast cell biology and function will provide therapeutic tools for mast cell-derived pathologies.
Techniques: Molecular, biochemical and cellular techniques.
What is the aim of the project?
Understand how mast cell responses are regulated. Deepen in the knowledge of mast cell biology and function will provide therapeutic tools for mast cell-derived pathologies
What techniques and methods are used?
Molecular, biochemical and cellular techniques.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to do bench work, learn techniques, interpret results and assist and participate in the seminars and lab discussions.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Once a week we discuss laboratory results. Once a week there is a seminar with the Immunoallergy and Clinic experimental group at IDIBAPS (Institut d’Investigacions Biomediques August Pi I Sunyer). IDIBAPS and the University organize periodically lectures.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Being organized, hard-working, and interested in basic research
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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