Projects
Name
Peripheral nerve regeneration and spinal cord injury
University
Catalonia (AECS) - Autonomous University of Barcelona (UAB) - Sciences Faculty, Barcelona
Domain
Physiology
Departement
Department of Cellular Biology, Physiology and Immunology
Head
Dr. Xavier Navarro Acebes
Tutor
Dr. Xavier Navarro Acebes
Languages
English and Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes No
Type of Research Project
- Basic science
What is the background of the project?
The Group of Neuroplasticity and Regeneration of the UAB is a multidisciplinary research group working on regeneration and recovery after peripheral nerve and spinal cord lesions and neurodegenerative diseases. Peripheral nerve injury is a major clinical and public health challenge. Actually, injuries to peripheral nerves, plexuses, and roots can be found in 5% of patients seen in civilian trauma centers. After axonotmesis, where the connective sheaths of the nerve are preserved and only the axons are injured, functional recovery is usually good. On the other hand, after nerve transection, axotomized neurons lose connections with their target organs and their distal axons degenerate resulting in loss of motor, sensory and autonomic functions conveyed by the injured nerve.
The research projects of the group during the last years have dealt with: regeneration and reinnervation after peripheral nerve injuries, biocompatible artificial nerve grafts, cell and gene therapies for the repair of injuries in the peripheral and central nervous system, neuropathic pain, physiopathology and new therapies for neurodegenerative diseases, and neural electrodes for interfacing the injured nervous system.
The members of the group have combined expertise in microsurgery, neurophysiology, morphology, cell culture, molecular neurobiology and bioelectronics.
What is the aim of the project?
The research projects of the group during the last years have dealt with: regeneration and reinnervation after peripheral nerve injuries, biocompatible artificial nerve grafts, cell and gene therapies for the repair of injuries in the peripheral and central nervous system, neuropathic pain, physiopathology and new therapies for neurodegenerative diseases, and neural electrodes for interfacing the injured nervous system.
What techniques and methods are used?
The members of the group have combined expertise in microsurgery, neurophysiology, morphology, cell culture, molecular neurobiology and bioelectronics.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will assist, help and learn the basic science activities that are performed routinely in our lab. He/she will attend internal weekly meetings for presentation and discussion of results, and for presentation of Journal club.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The Group of Neuroplasticity and Regeneration maintains an internal training program, which includes weekly meetings for presentation and discussion of results, and for presentation of Journal club, made mainly by PhD students and postdoctoral researchers and participation of all group members.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Physiology and Anantomy required. Neuroscience desired
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/22609046
- http://www.ncbi.nlm.nih.gov/pubmed/23098732
- http://www.ncbi.nlm.nih.gov/pubmed/23106494
- http://www.ncbi.nlm.nih.gov/pubmed/23201096
- http://www.ncbi.nlm.nih.gov/pubmed/24083438
- http://www.ncbi.nlm.nih.gov/pubmed/24093606