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Inflammation as therapeutic objective in stroke
Spain (IFMSA-SPAIN)-University of Castilla la Mancha, Albacete
Pharmacology department, Albacete
English or Spanish
Type of Research Project
- Basic science
What is the background of the project?
Ischemic stroke is the most frequent cause of persistent neurologic disability in modern Western societies. Although several approaches for anti-inflammatory treatment have proven effective in animal models, clinical trials of immune system modulation therapy after stroke have not yet proved successful. There is still much to be done in order to translate interesting findings into therapies, but undoubtedly studying the cellular and molecular pathways may not only improve our understanding of inflammatory mechanism but also serve as a basis for designing effective therapies.
What is the aim of the project?
Ischemic stroke is the most frequent cause of persistent neurologic disability in modern Western societies. Albeit it is still not clear whether inflammation is merely an epiphenomenon or rather has a disease-promoting function, accumulating evidence implicates inflammation in many forms of acute neurodegenerative disorders including ischemia. The immune cell influx during a neuropathological event is thought to be elicited by glial cells, especially microglia. This article reviews the cellular and molecular pathways involved in stroke-induced inflammatory response in the CNS.
What techniques and methods are used?
Western Blot, Immunofluorescence.
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student should be highly interested in Pharmacology research. He is required to be in the lab in the whole exchange and to be interested in what he is doing - he should help all the lab staff and to be dedicated. The student will participate in the practical collect of Data and interpretation of the results. The student will acquire practical skills in molecular biological, cell biological and immunologic methods.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is required that students have already passed pharmacology, biochemistry physiology, and histology.
Are there any legal limitations in the student’s involvement
Liability insurance needed
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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