Projects
Name
Dissecting the molecular mechanism of cilia and flagella structure and function: From ciliogenesis to ciliopathy
University
Japan (IFMSA-Japan) - Yamanashi University, Yamanashi
Domain
Anatomy
Departement
Department of Anatomy and Cell Biology, The University of Yamanashi
Head
Prof. Sen TAKAEDA, M.D., Ph.D.
Tutor
Keishi NARITA, Ken-taro YOSHIMURA, Tmohiko IWANO, Osamu KUTOMI
Languages
English, French,German,
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes No No No No Yes Yes Yes Yes No No
Type of Research Project
- Basic science
What is the background of the project?
Primary cilium is an organelle taking part in the cell motility and sensing the extracellular milieu. Although these tiny organelles are ubiquitously found in cells except for floating cells, we have very limited knowledge on their exact physiological roles. Especially, how the primary cilia regulate the brain function is a very intriguing issue, as many ciliopathies bring about mental retardation and cognitive dysfunctions.
The aim of our project is to elucidate the molecular mechanism of novel signal transduction via primary cilium in the nervous system. Our hypothesis is that the neuronal primary cilium may be responsible for fine tuning of the neural circuit, by a manner different from synaptic transmission.
In this project, interdisciplinary techniques in cell biology, molecular biology, genetics, bioinformatics, anatomy, histology (Light Microscope and Electron Microscope), and proteomics are required as a basic tool.

For those who enroll in our laboratory will be tutored by lab member for the basic techniques and modus operandi in research. Furthermore, they can attend the regular lab meeting, which will be held in English during the sojourn of students.
The exchange students are expected to take part in one of the projects currently run in the laboratory. However, due to the limitation of time, it is almost impossible to complete a work that deserves for the publication during their stay. However, depending on the degree of contribution of students, we will acknowledge him/her in the paper.
He/she may have a chance to make presentation in the lab meeting.
Students will acquire the basic skills in modern cell biology in this course. Techniques in electron microscopy as a tool for cell biology can be also acquired during the course.
What is the aim of the project?
To elucidate the molecular mechanism of novel signal transduction via primary cilium in the nervous system and immune system:While cilia are ubiquitously found in cells except for floating cells, we have very limited knowledges on their exact physiological roles. Especially, how the primary cilia regulate the brain function is a very intriguing issue, as many ciliopathies bring about mental retardation and cognitive dysfunctions. Our hypothesis is that the neuronal primary cilium may be responsible for modulating the neural circuit, tnrough a mechanism different from synaptic transmission.
What techniques and methods are used?
In this project, interdisciplinary techniques in cell biology, molecular biology, genetics, bioinformatics, anatomy, histology (LM and EM), and omics are required as basic tools.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The exchange students are expected to take part in one of the projects currently run in our laboratory. However, due to the limitation of time, it is almost impossible to complete a work that deserves for the publication during their stay. However, depending on the degree of contribution by students, we will be acknowledged him/her in the paper. The methods used include interdisciplinary techniques in cell biology, molecular biology, genetics, bioinformatics, anatomy, histology (LM and EM), and omics.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
For those who enroll in our laboratory will be tutored by lab member for the basic techniques and modus operandi in research. Furthermore, they can attend the regular lab meeting, which will be held in English during the sojourn of students.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The students should make themselves understood at least in English. Moreover, they are required to have basic knowledge in biology of undergraduate level.
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
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