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The role of intestinal microflora in pathogenesis of atherosclerosis, colorectal cancer and possibilities of modulation in both diseases prevention
University of Pavol Jozef Safarik
Department of Experimental Medicine, Faculty of Medicine, Pavol Jozef Safarik University
MVDr. Alojz Bomba, DrSc.
RNDr. Lucia Kulikova;, PhD., RNDr. Maria Chytilova, PhD.
Type of Research Project
- Basic science
What is the background of the project?
Atherosclerosis and cancer diseases are considered as variations of similar disease processes. Presumably, in both disease processes may be effective not only equal therapeutic but also preventive procedures. Intestinal flora can play a very important role in regulating the protective mechanisms of the body in several chronic diseases and may affect the molecular mechanisms of their pathogenesis. The current project is focused on the role of intestinal microflora in the pathogenesis of atherosclerosis and colorectal cancer and its possible modulation in their prevention.
What is the aim of the project?
The main objective of the project is to acquire new knowledges about the role of intestinal microflora in the regulation of protective mechanisms of the organism and its impact on cellular and molecular mechanisms in the pathogenesis of atherosclerosis and colorectal cancer and its possible modulation in the prevention of both diseases.
What techniques and methods are used?
What techniques and methods will be used?
Microbiological and biochemical techniques, cell cultures techniques, molecular analysis, theoretical training for working with the in vitro Simulator of Human Intestinal Microbial Ecosystem (TWINSHIME)
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Individual consultations and seminar.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have already studied preclinical subjects such as biology, biochemistry and microbiology. The main requirement is an active approach during the research fellowship.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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