Correlation of meningioma aggressiveness assessed by flow cytometry with diffusion tensor imaging (DTI) and dynamic susceptibility contrast (DSC) MRI
Greece (HelMSIC) - University of Ioannina, Ioannina
Radiology Department, Medical School of Ioannina
Prof. Maria I. Argyropoulou
Anastasia K. Zikou
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes No No No No Yes Yes Yes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Meningiomas are the most common benign intracranial tumor, accounting for 30% of all primary intracranial tumors. Although benign meningiomas rarely recur after a complete resection, anaplastic tumors are associated with high recurrence rate and unfavorable outcome. Flow cytometry is a technique for counting and examining microscopic particles, such as tumor cells, by suspending them in a stream of fluid and passing them by an electronic detection apparatus. Diffusion and perfusion MRI can be used to assess microvascular parameters and cellularity and have shown great promise for meningioma evaluation.

The aim of the project is the correlation of meningioma aggressiveness assessed by flow cytometry, with diffusion tensor imaging (DTI) and dynamic susceptibility contrast (DSC) MRI.

Techniques that will be used: flow cytometry, diffusion tensor imaging (DTI) and dynamic susceptibility contrast (DSC) magnetic resonance imaging.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Learn the methods of the research program and be involved in the experiments
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Preliminary readings will be required, and the appropriate materials will be supplied by the department. The student will use the imaging techniques mentionned adove and will make measurents on the patients.

The student must have basic Magnetic Resonance Imaging knowledge.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Correlation of diffusion tensor dynamic susceptibility contrast MRI and (99m)TcTetrofosmin brain SPECT with tumour grade and Ki-67 immunohistochemistry in glioma.Alexiou GA. Zikou A. Tsiouris S. Goussia A. Kosta P. Papadopoulos A. Voulgaris S. Kyritsis AP. Fotopoulos AD. Argyropoulou MI. Clin Neurol Neurosurg. 2014 Jan;116:41-5. doi: 10.1016/j.clineuro.2013.11.003. Epub 2013 Nov 16.