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Dissecting the role of miRNAs, tRNAs and essential protein synthesis factors in many disease models
Greece (HelMSIC) - University of Patras, Patra
Department of Biochemistry, School of Medicine, University of Patras, University Campus
Professor Denis Drainas
Associate Professor Constantinos Stathopoulos
Type of Research Project
- Basic science
What is the background of the project?
Many diseases, including bacterial infections, are regulated through RNA-mediated mechanisms (i.e RNA interference). Our group studies the role and involvement of many small RNA species (miRNAs, tRNAs, riboswitches) in the regulation of protein synthesis (both in transcriptional and in translational level) in many disease models.
The aim of the project is to get insights on the role of the level alterations of small regulatory RNAs and elucidate the mechanism underlying regulation and rate of protein synthesis.
Methods and techniques that will be used include qRT-PCR, PCR, DNA microarrays, cell cultures, fluorescent and confocal microscopy, gene cloning, expression and recombinant protein purification, bioinformatics
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Lab Techniques as stated in the background of the project.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There is no particulat requirements and skills required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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