Effect of physical exercise on heart function and central pressure in patients with different degree of renal dysfunction.
Poland (IFMSA-Poland) - Medical University of Lodz, Lodz
Dept. Nephrology, Hypertension and Kidney Transplantation
Professor Michal Nowicki, MD
Prof. Michal Nowicki, Dr Malgorzata Wajdlich
Polish, English, German
4 weeks
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Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The patients with chronic kidney disease have a high risk of cardiovascular morbidity and mortality. Most of them are hypertensive. In subjects with normal renal function short-term physica exercise induced a decrease of blood pressure but that could not be the case in patients with stiff arteries caused by medial calcification that is a typica finding in the presence of renal dysfunction. In such subjects brachial artery pressure may also not reflect central aortic pressure that is directly linked to left ventricular function.
What is the aim of the project?
To study the effect of physical exercise on left ventricular function, pulse wave velocity and central blood pressure in patients with chronic kidney disease with different degree of renal impairment and kidney transplant recipients.
What techniques and methods are used?
-non-invasive measurement of heart function with bioimpedance (PhysioFlow), pulse wave velocity and central blood pressure measurement with aplanation tonometry (Sphygmocor), exercise load will be measured with 3-axis accelerometer.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Participation and self-development.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of techniques used to measure heart and arterial function., also methods used in clinical research.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- useful key-words for Medline search: pulse wave velocity; central pressure; accelerometry; chronic kidney disease; arterial hypertension; heart rate variability