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Effect of sevoflurane, lidocaine and carvedilol modulating the inflammatory response to OLV
Spain (IFMSA-SPAIN)-University Complutense of Madrid, Madrid
Biochemistry and Molecular Biology III, Faculty of Medicine
M Dolores Blanco
English or Spanish
Type of Research Project
- Basic science
What is the background of the project?
One-lung ventilation (OLV) during thoracic surgery may induce an inflammatory response that can contribute to the induction and propagation of frequently occurring postoperative respiratory distress. Whether volatile or i.v. anaesthetics differentially modulate the alveolar inflammatory response to OLV is unclear.
What is the aim of the project?
Investigate the effect of OLV on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics lidocaine, carvedilol and sevoflurane.
What techniques and methods are used?
Forty-eight pigs undergoing thoracic surgery with OLV will be randomly assigned to receive anesthesia with intravenously applied propofol (alone or plus lidocaine or carvedilol) or the volatile anesthetic sevoflurane. Samples of bronchoalveolar lavage and blood will be taken before and after OLV to measure inflammatory mediators (tumor necrosis factor alpha, interleukin 1beta, interleukin 6, interleukin 8, interleukin 4, interleukin 10, NO, monocyte chemoattractant protein 1). Lung tissue from both collapsed and ventilated lungs will be analyzed for inflammatory mediators and stress kinases.
What is the role of the student?
- The tasks will be done under supervision
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
The student will work under our address on a research project focused on studying the effect of One Lung Ventilation (OLV) on the pulmonary inflammatory response and to assess possible immunomodulatory effects of the anesthetics (lidocaine - carvedilol and sevoflurane). He/she will be involved in several group activities such as basic biochemical and molecular measurements by ELISA and RT-PCR.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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