Neurobiological mechanisms underlying the curative effects of environmental stimulation on drug addiction
France (ANEMF) - Universite de Poitiers
Laboratory of Experimental and Clinical Neurosciences,INSERM U-1084, Poitiers
Mohamed JABER
Marcello SOLINAS
French English
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Basic science
What is the background of the project?
One of the hallmarks of addiction and one of its most troubling aspects is the long-lasting risk of relapse even after protracted period of abstinence. Using animal models of addiction, we have demonstrated that exposure to environmental stimulation during periods of abstinence reduce the risks of relapse.
This research project aims at elucidating the neurobiological mechanisms underlying the beneficial effects of environmental enrichment on drug addiction.
Our working hypothesis is that EE can reverse disruptions of neuroplastic adaptations that occur during the development of drug addiction and that are responsible for the chronic relapsing nature of drug addiction.
We will combine state of the art behavioral models of addiction and namely self-administration procedures with molecular biology techniques such as western blot and immunohistochemistry.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge of basic neuroscience is required.
For the use of students considering participating in the project, further information can be found from the following articles:
Solinas M, Chauvet C, Thiriet N, El Rawas R, and Jaber M. (2008) Reversal of cocaine addiction by environmental enrichment. Proc Natl Acad Sci U S A. 105(44):17145-50.
Solinas M, Thiriet N, Chauvet C and Jaber M. (2010) Prevention and treatment of drug addiction by environmental enrichment. Prog Neurobiol. 92(4):572-92.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Pre-Medical students from the American-British system
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