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(Concepcion) Site-directed Drug Delivery Using Dendrimer Nanoparticles
Universidad de Concepcion
Department of Phisiology, Faculty of Biological Sciences
Jorge Fuentealba, PhD.
Jose Leonardo Guzman, PhD.
English and Spanish
Type of Research Project
- Basic science
What is the background of the project?
Description: Dendrimers are polymers that have been used for drug solubility and for to increase the bioavailability of drugs. The most common use for these nanocarriers has been for treatment of cancer. However, just small advances has been achieved in the use of dendrimers in central nervous systems diseases or neuronal effects. In this project we will study the comparative effects of the use of dendrimers in the administration of drugs that affects neural tissues.
What is the aim of the project?
To direct the delivery of drugs in synaptic structures.
What techniques and methods are used?
Techniques and methods: Calcium measurements in living cells, electrophysiological techniques, cytological images in confocal microscopy.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
To design experimental protocols. To perform experiments in cells lines. To conclude in appropriate manner and according with the objectives of the project. It is expected that the student could generate one or two results that could be presented in a student meeting, understanding the theoretical basis of both the experiment and the technique used.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, preliminary readings and talks.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- A white coat is obligatory for this research project. - There are approximately 6 hours of work per day required. - It would be ideal to receive students that have approbed a biochemistry and a physiology course. Basic knowledge on cellular biology is also desirable.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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