Projects
Name
(Vina del Mar) Viral endogenous elements and their role in health and disease
University
Universidad Nacional Andres Bello - Vina del Mar
Domain
Microbiology
Departement
Department of Biological Sciences, Faculty of Biological Sciences, Andres Bello University
Head
Marco Alvarez, Ph.D.
Tutor
Gloria Arriagada, Ph.D.
Languages
English and Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes
Type of Research Project
- Basic science
What is the background of the project?
Viral endogenous elements are virus-derived genes that after infection of germ cell lines have establish themselves among different species. Why they remain in eukaryotic genomes still remains a question, but it has been proposed that they provide some advantage to the host. Some of them are expressed as protein, others are expressed as non coding or small RNAs, while others are kept silenced. The aim of this project is to understand how the expression or silencing of endogenous viral elements is regulated. Techniques: Using biochemistry, molecular biology, and bioinformatics we are evaluating if the expression of two particular viral endogenous elements occurs as protein or RNA, and how it is regulated.
What is the aim of the project?
The aim of this project is to understand how the expression or silencing of endogenous viral elements is regulated.
What techniques and methods are used?
Techniques: Using biochemistry, molecular biology, and bioinformatics we are evaluating if the expression of two particular viral endogenous elements occurs as protein or RNA, and how it is regulated.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
The student will have to immerse itself in the laboratory environment, will perform specific experiments, and will assist master and PhD students, also will participate of result discussion of other lab members, in weekly lab meetings. It is expected that the student works about 8hours per day.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will have the opportunity to present the results together with the supervisor at a conference
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- A white coat is obligatory for this research project.
- There are approximately 8 hours of work per day required.
- The exchange students participating in this project should be a student who has a solid foundation on cell biology, biochemistry, molecular biology and microbiology courses approved. There is no legal limitation for the student involvement in this project.
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- a:0:{}Arriagada G; Metzger MJ; Muttray AF; Sherry J; Reinisch C; Street C; Lipkin WI; Goff SP. Activation of transcription and retrotransposition of a novel retroelement; Steamer; in neoplastic hemocytes of the mollusk Mya arenaria. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14175-80. doi: 10.1073/pnas.1409945111.
- Arriagada G; Gifford RJ. Parvovirus-derived endogenous viral elements in two South American rodent genomes. J Virol. 2014 Oct;88(20):12158-62. doi: 10.1128/JVI.01173-14.